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Research has shown that when normal human bronchial epithelial cells are exposed to copper, it activates the expression of heat shock response genes, ubiquitin-related genes, and autophagy regulatory genes and causes degradation of proteasomes, resulting in an increase of misfolded proteins (48)

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PMID: 31321583 Probiotics Antimicrob ProteinsPangenome Analysis and Genome-Guided Probiotic Evaluation of Cyclic Dipeptides Producing Levilactobacillus brevis DY55bre Strain from a Lactic Acid Fermented Shalgam to Assess Its Metabolic, Probiotic Potentials, and Cytotoxic Effects on Colorectal Cancer Cells

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This balance, however, will be disrupted if there is an increase in ROS production or a decrease in cell antioxidant capacity, resulting in oxidative stress (46, 47)